Osu's Oxford Street houses one of Ghana's most vibrant business districts. Electronics, household decorations, food and ice cream, clothes (local and exotic), etc are sold and marketed here and with lots of variety too. There are also banks on hand to refill your pockets if you run out of cash.
Small scale business within the residential part of Osu leans heavily toward the food and entertainment industries. A small fashion business owner complained that people seem so much more interested in eating and partying than patronising other businesses such as hers. Though the real reason may be due to the fact that most people only emerge from the walls of their homes at night for some fun; when they are hungry; or on their way to some other parts of the city and country; and so, are very unlikely to notice business establishments whose services they are not, at those moments, considering.
There is a great number of drinking spots, eateries (Frankie's, Livingstone Safari Restaurant, Haveli [Indian Cuisine], Papaye [Fast Food], Asanka Locals [Traditional/Local Ghanaian Cuisine], Noble House Restaurant [Indian and Chinese Cuisine]), entertainment centres (Republic Bar & Grill, Osu Mall, etc), nightclubs (Duplex, Tantra, etc) and many more such businesses that fall within the food and entertainment industries. Much more detailed information can be found here.
Most of the telecommunications providers have offices located around here (mainly on the Oxford Street) and have really good reception, though some vendors in Nyaniba Estates complain that their customers sometimes have difficulty getting their recharge vouchers accepted when they try recharging within the estates. If you are interested in Osu for the location of your own business, you can find some office spaces for rent in Osu on meQasa.